Simon's two-stage
Webb3 apr. 2024 · Simon’s two-stage designs with binary endpoint. In Simon’s two-stage optimal designs, a trial is allowed to be stopped in the first stage when the number of … Webb5 juni 2024 · This function calculates the sample size needed in a Simon 2-stage design which is a two-stage design that is optimal in the sense that the expected sample size is minimized if the regimen has low activity subject to constraints upon the size of the type 1 and type 2 errors.
Simon's two-stage
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Webb1 juli 2024 · Objective: To compare Gehan two-stage design and Simon two-stage design in sample size calculations for phase Ⅱ clinical trials of anti-tumor drugs. Methods: We … WebbThe Simon two stage design consists of studying n1 participants in a first stage and the study stops if there are r1 or fewer responders to the intervention. If there are more than …
Webb20 maj 2024 · The article aims to compare the efficiency of minimax, optimal and admissible criteria in Simon’s and Fleming’s two-stage design. Three parameter settings … WebbSimon's Two Stage Phase II Design Worked Examples Title: A phase II trial of Sunitinib malate in recurrent and refractory ovarian, fallopian tube and peritoneal carcinoma Objective: To assess the efficacy and safety of Sunitinib® in recurrent ovarian, fallopian tube and peritoneal carcinoma. Year: 2013
Webbtype 2 errors and there was no attempt to be “optimal” in terms of minimising the expected sample size; this was introduced by the Simon two-stage design [5]. The Simon two … Webb17 jan. 2012 · The Simon two stage design consists of studying n1 participants in a first stage and the study stops if there are r1 or fewer responders to the intervention. If there are more than r1 responders in the first stage then the study continues until n participants in total are studied.
Webb16 dec. 2024 · PURPOSE Two-stage single-arm designs have historically been the most common design used in phase II oncology. They remain a mainstay today, particularly …
Webb2 aug. 2016 · Simon’s two-stage design is the most widely implemented among multi-stage designs in phase II clinical trials to assess the activity of a new treatment in a single-arm study. In this two-stage design, the … ram dnbWebb1 okt. 2015 · Abstract Two-stage designs are commonly used in phase II oncology trial to mitigate the risk of exposing patients to an inefficacious drug. Typically, the decision of moving into stage 2... driza-bone bushman oilskin heritage jacketWebb14 sep. 2015 · For phase II oncology trials, Simon's two-stage design is the most commonly used strategy. However, when clinically unevaluable patients occur, the total number of patients included at each... driza-bone hatWebb21 okt. 2024 · The Simon two-stage approach involves two criteria, minimax and optimal, for selecting sample sizes and critical values for these two-stage designs. Usually, the … ram dodge pickupWebb11 dec. 2024 · A Two-stage Simon Design Phase II Study for NOn-BRCA Metastatic BReast Cancer (MBC) Patients With Homologous Recombination Deficiency Treated With … drizabone coats ukWebbP-values Under Simon’s Two-Stage Design Alex Karanevich and Michael Ames, EMB Statistical Solutions ABSTRACT Simon’s two-stage designs are popular single-arm, … driza bone coatsWebb1 mars 2016 · Holmgren (JH) Jones CL, Holmgren E: ‘An adaptive Simon two-stage design for phase 2 studies . of targeted therapies’, Contemporary Clinical Trials 28 (2007) 654 … driza-bone hut