WebSep 15, 2000 · PPARs are transcription factors that bind to regulatory regions of target genes and activate transcription in response to the binding of lipid-like molecules. 891011 Three PPAR family members are known: α, γ, and δ. The function of the ubiquitously expressed PPARδ is not yet clear. WebPeroxisome proliferator–activated receptors (PPARs) are nutrient-sensing nuclear transcription factors, of which PPARγ is of special interest in the context of Na + and …
Modulation of peroxisome proliferator-activated receptors
WebMar 21, 2024 · Peroxisome proliferator-activated receptors (PPARs) are essential nuclear hormone receptors regulating metabolic processes, and they participate in the initiation and progression processes of tumors. Gastrointestinal (GI) cancer is a prevalent malignancy worldwide that originates from the tissues of the gastrointestinal tract and is ... WebDec 12, 2016 · PPARα is a nuclear receptor that maintains lipid homeostasis by modulating an array of target genes participating in lipid catabolism, lipoprotein assembly and transport, as well as thermogenesis [ 12, 13 ]. hdfc bank dap pl
Peroxisome proliferator-activated receptors regulate the …
WebMar 25, 2024 · Growing evidence suggests a role for peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in the angiogenesis, growth, and metastasis of solid tumors, but little is known about its role in multiple myeloma (MM). Angiogenesis in the bone marrow (BM) is characteristic of disease transition from m … WebMar 27, 2024 · Peroxisome proliferator-activated receptor γ (PPARγ) is known to regulate cell survival mechanisms such as hypoxia, oxidative stress, inflammation and energy … WebJan 1, 2005 · Here, we identify the nuclear receptor peroxisome proliferator-activated receptor-α (PPAR-α) as the molecular target responsible for the anti-inflammatory properties of PEA. PEA selectively activates PPAR-α in vitro with an EC 50 value of 3.1 ± 0.4 μM and induces the expression of PPAR-α mRNA when applied topically to mouse skin. hdfcbank dap link